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作用部位
肺・気道局所
作用機序
一般に、ステロイドは細胞質内のグルココルチコイド受容体に結合し、複合体を形成し活性化する。受容体複合体は核内へ移行し、DNA上のグルココルチコイド応答性エレメントに結合し、標的となる遺伝子転写を促進または抑制する。その結果、炎症に関与するケミカルメディエーターやサイトカインなどの産生を遺伝子レベルで調節し、抗炎症作用を発揮する。
稲垣直樹：Prog Med 2007；27（6）, 1282-1288
製品名はすべて、グラクソ・スミスクライン、そのライセンサー、提携パートナーの登録商標です。
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